EyeCane虚拟和真实导航训练中的功能磁共振成像实验任务序列。(A)扫描仪内的范式;两组都在三种积木上进行测试，而盲人组只在一个积木上进行训练。这3个方块分别是迷宫1训练(盲者训练)、迷宫2不训练(盲者未训练)和一个打乱的任务(作为对照任务)。每个块每次重复4次，每个扫描日2次。(B)实验方案包括训练前的fMRI扫描，然后在真实和虚拟环境中进行3天的训练，以及训练后的扫描。(C) EyeCane设备，一种独特的视觉到听觉感官替代设备(SSD)，可以将距离信息映射到声音中。(D)迷宫1训练设置;数字与错误率相对应，并基于偏离正确路径的情况。(E)设置新奇迷宫2无需训练; numbers correspond to errors rate and are based on deviance from the correct path. (F) Heatmaps of the path taken by the CB pre-training, CB post-training, and sighted groups in maze 1 training during the scan for each of the groups. The heatmap represents the amount of time spent by each participant in the different areas of the maze for both the PRE (pre-training) and POST (post-training) conditions. The time spent in each point was defined by calculating the time between 2 key strokes (a key stroke represents a step), see STAR Methods. Hotter colors indicate that on average, participants in that group spent more time in that location. The heatmaps show that in the post-training condition, the blind participants were able to find the exit to the maze similarly to the sighted. Credit:当代生物学(2023)。DOI: 10.1016 / j.cub.2023.02.025
