Science Signaling is a weekly journal, publishing 51 issues a year, as well as an online resource and information management tool that enables experts and novices in cell signaling to find, organize, and utilize information relevant to processes of cellular regulation. The overarching goal of Science Signaling is publish key findings of broad relevance in the field of cell signaling and to provide articles, community features, tools, and online resources that enable readers to gain insight into cellular regulatory processes. An additional goal of the site is to provide an authoritative database of cell signaling information that is accessible to readers and useful for computer-based analysis.
Two drugs approved decades ago not only counteract brain damage caused by Alzheimer's disease in animal models, the same therapeutic combination may also improve cognition.
Chronic viral infections in the liver can lead to organ dysfunction and ultimately to liver tumors in a progression invariably characterized by viruses that proliferate free of immune system restraints.
Just as it is for marathoners who've completed a 26-mile run, or shrubs that have gone without water in a heatwave—exhaustion is an unavoidable fact of life. Dogs get exhausted after herding sheep; birds turn in for the ...
When pathogens invade or tumor cells emerge, the immune system is alerted by danger signals that summon a key battalion of first responders, the unsung heroes of the immune system—a population of starfish-shaped sentinels ...
Canadian immunologists have identified a mechanism that promotes the activation of T cell receptors by altering how one of its components interacts with the cell membrane.
A naturally occurring antibody capable of stimulating the body's immune-suppressing regulatory T cells has been discovered by a team of Harvard scientists, a finding that may eventually open a new door into kinder, gentler ...
Mutations in a vital class of regulatory molecules are an underappreciated cause of cancer because they impair the function of "G" proteins, a versatile and vast family of signaling switches that underlie innumerable biological ...
What do a scraped knee, a paper cut, or any form of surgery have in common? The short answer is a wound in need of healing—but the long answer lies in a series of biological activities that allow tissues to repair themselves.
科学家破译通过的一项关键战略r cells that allows them to outfox the immune system and enhance the odds of their survival by employing a deadly "two-faced protein" that is reminiscent of a two-faced figure ...
No matter the pathogen—virus, bacterium or fungus—many "pick a specific type of lock" on the surface of cells, which allows the microbe to break and enter into the inner sanctum of the host's genome.
