全国大学的研究人员Singapore and colleagues in the US and China undertook a two-decade metabolic analysis of Global Burden of Disease (GBD) reports. They have published their findings in the journal ...
From the DNA of nearly 300,000 veterans, scientists have singled out a handful of genetic mutations that not only govern levels of cholesterol, but may also inform the development and use of drugs for cardiovascular disease ...
Oct 1, 2018
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Approximately 40% of persons with diabetes develop chronic kidney disease, leading to successive deterioration and even the complete loss of kidney function. Until now, it has not been possible to predict whether and at what ...
Apr 24, 2023
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New evidence released today from a study of 31,245 patients already taking statin therapy indicates that inflammation may be a more powerful predictor of risk of future cardiovascular events—such as heart attack and stroke—than ...
Mar 6, 2023
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Heart disease is the leading cause of death worldwide, killing someone in the United States every 34 seconds, according to the Centers for Disease Control and Prevention. A new study by investigators from Brigham and Women's ...
Feb 28, 2023
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A new Australian population-based cohort study by Monash University has directly compared two classes of drugs used to treat type 2 diabetes (T2D) and found that one of the two classes is associated with a greater reduction ...
Jan 31, 2023
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After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are available ...
Nov 17, 2022
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A team of researchers at AstraZeneca, working with colleagues from the University of Mexico and the University of Oxford, has found that a protein tied to the MAP3K15 gene variant may represent a potential target for managing ...
Heart disease is the leading cause of death in the United States and around the world. Lowering high blood pressure and cholesterol could help to reduce morbidity and mortality, but frequent in-person visits to measure and ...
Nov 9, 2022
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The discovery of a genetic variant that is relatively common among people of Polynesian ancestry, but incredibly rare in most other populations, is giving clues to the genetic underpinnings of high cholesterol in all people, ...
2022年10月20日
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Cholesterolis a lipidic, waxy steroid found in the cell membranes and transported in the blood plasma of all animals. It is an essential component of mammalian cell membranes where it is required to establish proper membrane permeability and fluidity. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Cholesterol is classified as a sterol.
Since cholesterol is essential for life, it is primarily synthesized de novo within the body. However excessive levels of cholesterol in blood circulation are strongly associated with progression of atherosclerosis. For an adult, typical total body cholesterol synthesis is about 1 gram per day (less if dietary intake is high) and total body cholesterol content is about 35 g. Average dietary intake in western societies is 0.2 - 0.3 grams. Cholesterol is excreted by the liver via the bile into the digestive tract. Typically about 50% of the excreted cholesterol is reabsorbed by the small bowel back into the blood stream.
The name cholesterol originates from the Greekchole-(bile) andstereos(solid), and the chemical suffix-olfor an alcohol, as François Poulletier de la Salle first identified cholesterol in solid form in gallstones, in 1769. However, it was only in 1815 that chemist Eugène Chevreul named the compound "cholesterine".
This text uses material fromWikipedia, licensed underCC BY-SA
