Diseases, Conditions, Syndromes

Superbugs pose 'huge challenge' in treating Ukraine war wounds

Infections with superbugs that are resistant to most drugs have presented a "huge challenge" in treating the devastating injuries of people wounded in the war in Ukraine, doctors in Germany said on Tuesday.

Obstetrics & gynaecology

Preclinical study identifies new target for recurrent ovarian cancer

Despite recent advances, ovarian cancer remains the fifth leading cause of cancer-related deaths among women, and there's a critical need for new treatment options, especially for advanced cancers that grow back after standard ...

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Resistance-fighting antimalarial drug candidate enters the clinic

A new antimalarial drug candidate, discovered through a longstanding collaboration between WEHI and global biopharmaceutical company MSD has entered Phase 1 clinical testing in healthy participants. The candidate drug inhibits ...

Medications

Study finds evidence of resistance to COVID-19 drugs

Resistance to Paxlovid is already evident among viral SARS-CoV-2 variants currently circulating globally, indicating that this stand-alone drug known as a protease inhibitor could soon become less effective in treating COVID-19 ...

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Drug resistance

Drug resistanceis the reduction in effectiveness of a drug in curing a disease or improving a patient's symptoms. When the drug is not intended to kill or inhibit a pathogen, then the term is equivalent todosage failureordrug tolerance. More commonly, the term is used in the context of diseases caused by pathogens.

Pathogens are said to bedrug-resistantwhen drugs meant to neutralize them have reduced effect. When an organism is resistant to more than one drug, it is said to be multidrug resistant.

Drug resistance is an example of evolution in microorganisms. Individuals that are not susceptible to the drug effects are capable of surviving drug treatment, and therefore have greater fitness than susceptible individuals. By the process of natural selection, drug resistant traits are selected for in subsequent offspring, resulting in a population that is drug resistant.

This text uses material fromWikipedia, licensed underCC BY-SA