胎盘缺乏SARS-CoV-2病毒用来引起感染的主要分子

根据研究人员的研究国家卫生研究院。他们的发现出现在期刊上el。

这些胎盘组织也缺少制造一种被称为TMPRSS2的酶所需的信使rna，这种酶是SARS-CoV-2用来进入细胞的。该研究的作者说，这种受体和酶在胎盘中只存在极少量，这可能解释了为什么SARS-CoV-2很少在感染该病毒的妇女的胎儿或新生儿中发现。

The researchers, led by Roberto Romero, M.D., chief of the Perinatology Research Branch at NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), found that the placenta contains molecules that previous studies have suggested as potential routes for SARS-CoV-2 infection, including the CD147 receptor and the enzymes cathepsin L and Furin. They also detected in placental and membrane tissue a type of macrophage (immune cell) that has the ACE2 receptor. However, they noted that there is little evidence showing that infected macrophages could spread the SARS-CoV-2 virus to the placenta, membranes and fetus in normal pregnancy.

最后，研究人员发现胎盘中含有大量用于感染寨卡病毒和巨细胞病毒的受体，这两种病毒在怀孕期间从妇女传给胎儿时会带来严重的健康风险。

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