Researchers at Case Western Reserve University School of Medicine have discovered a mutant form of the gene, Chk1, that when expressed in cancer cells, permanently stopped their proliferation and caused cell death without ...
Aug 1, 2012
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In a small patch of skin no bigger than an inch, there are millions of cells all performing duties, like protecting us from bacteria and sensing temperature. A portion of them are melanocytes, a type of cell dedicated to ...
Aug 4, 2022
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The discovery of insulin 100 years ago opened a door that would lead to life and hope for millions of people with diabetes. Ever since then, insulin, produced in the pancreas, has been considered the primary means of treating ...
Jan 4, 2022
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Researchers from North Carolina State University have discovered that a particular molecular signaling pathway plays an important role in producing osteoarthritis (OA) pain. Using a mouse model of painful osteoarthritis, ...
Jan 27, 2022
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Scientists at the Oklahoma Medical Research Foundation have broken new ground in understanding how the lymphatic system works, potentially opening the door for future therapies.
Oct 16, 2018
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When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells. The same thing happens when an injured muscle starts to ...
Feb 26, 2021
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Researchers at the Columbia University College of Dental Medicine have determined how F. nucleatum—a common oral bacteria often implicated in tooth decay—accelerates the growth of colon cancer. The study was published ...
Mar 4, 2019
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Maintaining a regular workout routine can help you look and feel great—but did you know that exercise also helps maintain your muscles and bones? People who are unable to engage in physical activity experience weakening ...
Sep 13, 2022
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While investigating why cholesterol-lowering drugs called statins cause negative side effects such as blurred vision, short-term memory loss or increased risk for diabetes, cellular chemists at The University of Toledo discovered ...
Mar 19, 2019
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科学家们已经确定了一个致癌基因(cancer-causing gene) responsible for glioblastoma, the deadliest brain tumor. The discovery offers a promising new treatment target for a cancer that is always fatal.
Jul 14, 2020
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In biology, 'signal transduction'refers to any process by which a cell converts one kind of signal or stimulus into another. Most processes of signal transduction involve ordered sequences of biochemical reactions inside the cell, which are carried out by enzymes and activated by second messengers, resulting in asignal transduction pathway. Such processes are usually rapid, lasting on the order of milliseconds in the case of ion flux, or minutes for the activation of protein- and lipid-mediated kinase cascades, but some can take hours, and even days (as is the case with gene expression), to complete. The number of proteins and other molecules participating in the events involving signal transduction increases as the process emanates from the initial stimulus, resulting in a "signal cascade," beginning with a relatively small stimulus that elicits a large response. This is referred to asamplification of the signal.
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