//www.puressens.com/ en-us provides the latest news from Beth Israel Deaconess Medical Center 超过20个美国高中学生试验enced homelessness in 2016 and 2017, according to a 2018 report from the United States Department of Housing and Urban Development. While the circumstances surrounding these adolescents' homelessness are undoubtedly stressful and traumatic, few reliable and large-scale assessments of the psychiatric burden among homeless teens are available.//www.puressens.com/news/2022-05-mental-health-substance-adolescents-experiencing.html Psychology & Psychiatry Tue, 10 May 2022 12:15:08 EDT news571403705 Diabetes is a leading cause of death and disability in the United States, affecting more than 34 million adults and generating $330 billion in annual healthcare expenditures. Excess body weight is one risk factor that increases one's odds of developing diabetes, and federal guidelines recommend starting screening at age 35 for all overweight adults—defined as those who have a body mass index (BMI) of 25 or higher.//www.puressens.com/news/2022-05-screening-patients-sooner-racial-ethnic.html Diabetes Mon, 09 May 2022 17:00:01 EDT news571332276 By now, many have become all too familiar with rapid antigen tests for diagnosis of COVID-19. Slightly less accurate than the genetic tests administered by healthcare professionals, the rapid antigen tests' ease-of-use allows the general public to monitor themselves for COVID-19 infections at home and make timely decisions to help stop the spread. The home tests, however, were developed and granted federal authorization for use with the original SARS-CoV-2 viral strain that emerged late in 2019. Since then, the virus has evolved countless times, and several viral variants of concern have emerged, including the highly infectious delta and omicron variants that swept across the United States last summer and winter respectively.//www.puressens.com/news/2022-05-rapid-antigen-covid-pace-variants.html Diseases, Conditions, Syndromes Thu, 05 May 2022 14:44:53 EDT news570980691 While the COVID-19 epidemic may have taken over the headlines the last two years, the United States remains in the grip of the opioid epidemic. Nearly 70,000 Americans died from opioid overdoses in 2020, the last year for which there are federal statistics available. New research may suggest fewer of those deaths are attributable to prescription opioids, the result of years-long efforts by physicians and other providers to reverse overprescribing trends. Prescribing patterns, including those after surgery, have been implicated as a significant contributor to the U.S. opioid crisis.//www.puressens.com/news/2022-05-machine-learning-assisted-overprescribing-underprescribing-opioids.html Addiction Wed, 04 May 2022 12:11:04 EDT news570885061 An estimated 25 percent of people older than 65 have type 2 diabetes, a condition in which the body cannot produce enough insulin to effectively manage blood sugar. Insulin plays an important role in the brain, and people with prediabetes and diabetes are at increased risk of Alzheimer's disease and cognitive decline. Delivering insulin to the brain intranasally—atomized and sprayed through the nose—has been shown to improve verbal memory and has emerged as a potential treatment for cognitive decline in the elderly.//www.puressens.com/news/2022-04-insulin-gait-cognitive-function-patients.html Medications Fri, 29 Apr 2022 13:26:12 EDT news570457568 Delirium is a serious change in brain function that affects up to 64% of older medical patients and up to 50% of older surgical patients. It can manifest as sudden confusion, agitation, memory loss or hallucinations and delusions. Estimated to cost the U.S. health care system as much as $182 billion annually, delirium is linked with longer hospital stays, complications and increased risks of dementia and death.//www.puressens.com/news/2022-03-scoring-tool-severity-delirium.html Psychology & Psychiatry Thu, 31 Mar 2022 16:05:05 EDT news567961503 Once considered to be inert, white adipose tissue is now recognized to be dynamic and to play an interactive role in a wide array of biological and metabolic processes. Diet and energy expenditure can cause dramatic changes to the physiology, behavior and cellular make-up of white adipose tissue, and these changes, in turn, are linked with metabolic diseases, including type 2 diabetes.https://phys.org/news/2022-03-cell-white-fat-tissue-mice.html Cell & Microbiology Thu, 17 Mar 2022 10:59:16 EDT news566733553 On January 11, the United States reported a record-breaking 1.35 million new COVID-19 infections, shattering the previous record set just eight days before. The sky-high case rate—roughly four times higher than numbers of daily infections seen last January—are a testament to the transmissibility of the Omicron variant. A highly mutated version of SARS-CoV-2, the virus that causes COVID-19, the Omicron variant has been shown to cause breakthrough infections among the vaccinated thanks to its ability to evade the virus-killing neutralizing antibodies that the body makes in response to getting vaccinated.//www.puressens.com/news/2022-01-current-covid-vaccines-robust-cellular.html Diseases, Conditions, Syndromes Mon, 31 Jan 2022 16:04:38 EDT news562867475 Coronary heart disease, which is a major cause of heart attack, develops when damaged or clogged arteries cannot deliver enough oxygen-rich blood to the heart. Black Americans are at greater risk of coronary heart disease than non-Hispanic white individuals; however, because Black Americans are underrepresented in clinical research, established risk prediction models do not fully capture their risk.//www.puressens.com/news/2022-01-scientists-predictors-heart-disease-black.html Cardiology Fri, 21 Jan 2022 17:50:48 EDT news562009838 Rural Americans are less likely to have health insurance, have less access to healthcare services for urgent conditions and are more likely to encounter lower quality care than their urban counterparts, according the Centers for Disease Control and Prevention. These factors combined with others mean the 46 million people, or 15 percent of Americans, who live in rural places are more likely to die of cancer, respiratory diseases and cardiovascular diseases than urban Americans.//www.puressens.com/news/2022-01-rural-patients-cardiovascular-die-heart.html Cardiology Tue, 18 Jan 2022 12:44:44 EDT news561732280 The placebo effect is the well-known phenomenon of a person's physical or mental health improving after taking a treatment with no pharmacological therapeutic benefit—a sugar pill, or a syringe full of saline, for example. While the exact biological, psychological and genetic underpinnings of the placebo effect are not well understood, some theories point to expectations as the primary cause and others argue that non-conscious factors embedded in the patient-physician relationship automatically turn down the volume of symptoms. Sometimes placebo effects can also harm –the so-called "nocebo effect" occurs when a person experiencing unpleasant side effects after taking a treatment with no pharmacological effects. That same sugar pill causing nausea, or that syringe full of saline resulting in fatigue.//www.puressens.com/news/2022-01-placebo-effect-accounts-two-thirds-covid-.html Vaccination Tue, 18 Jan 2022 11:00:02 EDT news561713660 Diabetic foot ulcerations—open sores or wounds that refuse to heal—are a devastating complication affecting more than 15 percent of people with diabetes and resulting in more than 70,000 lower extremity amputations per year in the United States alone. Notably, more than half of patients undergoing amputations due to diabetic foot ulcerations are expected to die within five years—a mortality rate higher than most cancers. Yet, the biological processes at work in diabetic foot ulcerations are poorly understood.//www.puressens.com/news/2022-01-scientists-skin-cells-contribute-diabetic.html Diabetes Mon, 10 Jan 2022 13:11:59 EDT news561042711 More than half of adults 65 and older report taking four or more prescription drugs, according to a 2019 Kaiser Family Foundation report. In an effort to reduce potential adverse events, there's been a recent movement to de-prescribe, or cut down on the number of medications taken by older patients. A 36-month long observational study called the Trial of Nonpharmacologic Interventions in the Elderly, or TONE, found that weight loss and reduced sodium diets could effectively replace the use of hypertension medications in older adults. However, the longer-term effects of de-prescribing hypertension medications on patients' blood pressure, risk of fainting and/or falling and other adverse effects were not reported.//www.puressens.com/news/2021-11-lifestyle-interventions-blood-pressure-medications.html Health Tue, 30 Nov 2021 15:12:34 EDT news557507551 Since March of 2020, the COVID-19 pandemic has put an unprecedented strain on the American health care system as large surges of intensive care unit patients overwhelmed hospitals. Facing this challenge, Beth Israel Deaconess Medical Center (BIDMC) expanded ICU capacity by 93 percent and maintained surge conditions during the nine weeks in the spring of 2020.//www.puressens.com/news/2021-11-frontlines-lessons-critical-nursing-covid-.html Diseases, Conditions, Syndromes Tue, 30 Nov 2021 12:48:16 EDT news557498893 In a recent phase 2b/3 clinical trial, a third mRNA vaccine against COVID-19—known as CVnCoV and developed by CureVac—reported approximately 48 percent efficacy against symptomatic disease. CV2CoV is a second generation vaccine developed by CureVac with noncoding modifications to optimize the vaccine. Researchers at Beth Israel Deaconess Medical Center (BIDMC) conducted a head-to-head test of the second-generation vaccine CV2CoV compared with CVnCoV. The scientists assessed the vaccines' ability to provoke an immune response as well as their protective efficacy against COVID-19 in non-human primates. Their findings are published in Nature.//www.puressens.com/news/2021-11-optimized-second-generation-mrna-vaccine-covid-.html Vaccination Thu, 18 Nov 2021 12:02:50 EDT news556459365 Each year, one million Americans undergo percutaneous coronary intervention after a heart attack, or to alleviate symptoms of chest pressure. Current American Heart Association guidelines recommend that patients who undergo PCI, a minimally invasive procedure to open clogged arteries, be prescribed dual antiplatelet therapy (DAPT) to prevent blood clots, and that they continue using the combination of aspirin and a second antiplatelet medication for at least one year after the procedure with continuation of DAPT beyond one year for patients with acceptable bleeding risk.//www.puressens.com/news/2021-11-approach-blood-clots-stent-placement.html Cardiology Wed, 10 Nov 2021 16:15:53 EDT news555783350 The 2021–22 school year represents the third academic year disrupted by the COVID-19 pandemic. Across the country, universities are implementing various vaccination, masking and distancing policies; however, there's little evidence about the risk of the spread of COVID-19 at social gatherings among university students to guide schools' policies.//www.puressens.com/news/2021-10-madness-temporary-covid-cases-counties.html Diseases, Conditions, Syndromes Mon, 25 Oct 2021 11:00:02 EDT news554371129 Based on the strength of clinical trial data showing the vaccines conferred robust protection against COVID-19, the U.S. Food & Drug Administration granted emergency use authorization to the mRNA-based vaccines known as BNT162b2 (BioNTech, Pfizer) and mRNA-1273 (Moderna) in December 2020, and to the Ad26.COV2.S (Johnson & Johnson) single-shot vaccine in February 2021. To date, nearly 200 million Americans have received a COVID-19 vaccine, and as some approach the one-year anniversary of their immunization, questions remain about the vaccines' long-term efficacy.//www.puressens.com/news/2021-10-months-immune-responses-elicited-covid-.html Vaccination Fri, 15 Oct 2021 10:17:11 EDT news553511827 In the 40 years since the first published reports of the syndrome known as AIDS, more than 32 million people have died from the virus that causes it, the human immunodeficiency virus (HIV). With more than 35 million people worldwide living with HIV today and nearly two million new cases each year, HIV remains a major global epidemic.//www.puressens.com/news/2021-10-elite-neutralizing-antibody-long-term-viral.html Immunology Thu, 14 Oct 2021 15:52:18 EDT news553445535 Estimated to cause almost half a million infections per year, the bacterium Clostridioides difficile, also known as C. difficile or "C. diff," can cause diarrhea and inflammation of the large intestine. Most often affecting patients who are older and/or have weakened immune systems, C. difficile infections are especially common among hospitalized patients and in patients who have recently completed a course of antibiotics. While several tests can detect the presence of C. difficile, healthy people can harbor the bacterium without becoming ill. A quantitative relationship between C. difficile and disease severity had not been clearly established.//www.puressens.com/news/2021-10-high-toxin-linked-severe-difficile.html Diseases, Conditions, Syndromes Tue, 12 Oct 2021 16:39:53 EDT news553275587 The existence of age, race and sex disparities in healthcare delivery within the United States is well established, with prior studies identifying inequitable treatment in common cardiovascular diseases such as hypertension, coronary artery disease and heart failure. However, it remains unclear if similar disparities exist in echocardiography a common heart-imaging procedure that nearly one in four Medicare beneficiaries receive during a given year.//www.puressens.com/news/2021-10-sex-age-disparities-echocardiography.html Cardiology Wed, 06 Oct 2021 12:15:05 EDT news552741297 Chronic back pain is the leading cause of disability worldwide. In the United States, patients spend up to $300 billion each year to treat the condition, according to a 2012 study published in the Journal of Pain. However, common therapies such as surgery and steroid injections intended to address physical origins of back pain have not been clearly proven to work in randomized clinical trials, and a growing body of evidence suggests that psychological factors may be associated with of some forms of back pain.//www.puressens.com/news/2021-09-mind-body-outperforms-treatment-chronic-pain.html Neuroscience Tue, 28 Sep 2021 10:35:07 EDT news552044104 Colorectal cancer is the third most diagnosed cancer and the second leading cause of cancer deaths in the United States. Regular screening for pre-cancerous lesions called adenomas has been shown to reduce the risk of death from colon cancer by more than 60 percent. However, adenoma detection rates and, conversely, adenoma miss rates vary greatly across physicians, with miss rates ranging from six percent to 41 percent.//www.puressens.com/news/2021-09-first-of-its-kind-computer-assisted-colonoscopies-lesions.html Oncology & Cancer Fri, 17 Sep 2021 10:51:10 EDT news551094667 In June 2021, the Food & Drug Administration (FDA) granted accelerated approval for aducanumab to treat patients with mild cognitive impairment or mild dementia due to Alzheimer's disease. The two phase-3 clinical trials of aducanumab on which the drug's approval was based showed increased risk of certain adverse vascular events. Though the clinical trials excluded participants based on advanced age, certain chronic diseases and use of anti-clotting medications, FDA approval was granted without contraindications or precautions for use of the drug in these patient populations.//www.puressens.com/news/2021-09-alzheimer-patients-eligible-forclinical-trials.html Alzheimer's disease & dementia Thu, 09 Sep 2021 16:07:48 EDT news550422465 Eighteen months into the pandemic, monoclonal antibodies remain the only FDA-authorized outpatient treatment for patients with symptomatic COVID-19. Laboratory-made proteins that mimic the immune system's ability to target and block the virus that causes COVID-19 from infecting human cells, monoclonal antibodies have been shown to reduce the risk of the most severe symptoms of COVID-19 and of being admitted to the hospital. While the federal government has distributed over one million antibody treatments to states, prior anecdotal reports suggested they may have been underutilized.//www.puressens.com/news/2021-09-uptake-fda-authorized-monoclonal-antibody-treatments.html Diseases, Conditions, Syndromes Wed, 08 Sep 2021 16:26:16 EDT news550337173 Black adults are disproportionately affected by cardiovascular disease but underrepresented in cardiovascular disease clinical research trials in the United States. The National Institutes of Health (NIH) recommends that studies should define goals for the recruitment of underrepresented clinical trial participants. However, few studies have evaluated whether newer recruitment strategies, such as the use of electronic medical record-based recruitment, are effective tools for recruiting Black participants, and no review to date has characterized the use of these methods among cardiovascular clinical trials.//www.puressens.com/news/2021-08-efforts-black-adults-cardiovascular-disease.html Cardiology Wed, 25 Aug 2021 15:18:44 EDT news549123514 A structure located at the base of the brain, the hypothalamus, orchestrates motivational states including hunger, thirst, and the motivation to mate. In a study published in the journal Nature, researchers at Beth Israel Deaconess Medical Center (BIDMC) uncovered the precise hypothalamic neurons that regulate the drive to engage in mating behaviors in mice. By identifying the molecular mechanism that sustains this motivational drive for many tens of minutes, the findings suggest a general principle about the neurobiology of motivation. The study also sets the stage for developing a targeted therapy to offset the sexual side effects linked to antidepressants that can discourage patients from treating mental illnesses.//www.puressens.com/news/2021-08-brain-circuitry-mice.html Neuroscience Wed, 25 Aug 2021 12:45:28 EDT news549114322 As the highly transmissible delta variant of the virus that causes COVID-19 surges in the United States and around the world, rapid and accessible COVID-19 testing and increased vaccination are key to managing the virus' spread. Nasopharyngeal (NP) swabs—long, medical-grade probes used to collect samples from deep in patients' noses and throats—are the gold standard for COVID-19 diagnostic testing. However, memory of shortages of both the specialized NP swabs during the early days of the pandemic as well as pressure on the trained medical personnel needed to perform the tests point to the need for simpler COVID-19 testing.//www.puressens.com/news/2021-08-clinical-trial-saliva-covid-reliable.html ob欧宝直播nba Fri, 20 Aug 2021 08:31:46 EDT news548667101 Gender-affirming hormone therapy is the bedrock of medical therapy for many transgender and gender diverse individuals. Some adult transgender individuals decide with their health care provider to start hormone therapy—testosterone for transmasculine people and generally a combination of estrogen and antiandrogens for transfeminine people—specifically for the physical and psychological effects these hormones produce, including changes to the voice, skin, facial and body hair and body composition. However, in the context of the global obesity epidemic, little is known about obesity rates and weight changes in adults treated with gender-affirming hormone therapy.//www.puressens.com/news/2021-08-longest-kind-reveals-gender-affirming-hormone.html Overweight & Obesity Fri, 20 Aug 2021 02:53:48 EDT news548646820 As of April 2021, federal law requires U.S. healthcare organizations to provide patients with access to their electronic health records, including outpatient visit notes. Previous studies have shown that patients who read their visit notes report feeling more in control of their care, remembering their care plan better and trusting their clinicians more. Patients with a single chronic condition, such as diabetes, report that they better understand their medications and potential side effects.//www.puressens.com/news/2021-08-older-patients-chronic-conditions-view.html Health Wed, 18 Aug 2021 03:23:23 EDT news548475798